{"id":10908,"date":"2024-06-03T10:40:39","date_gmt":"2024-06-03T15:40:39","guid":{"rendered":"https:\/\/www.sleepmeeting.org\/?p=10908"},"modified":"2024-06-03T10:40:39","modified_gmt":"2024-06-03T15:40:39","slug":"low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss","status":"publish","type":"post","link":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/","title":{"rendered":"Low-dose aspirin reduces inflammation caused by sleep loss"},"content":{"rendered":"

DARIEN, IL \u2013 A new study to be presented at the SLEEP 2024 annual meeting found that low-dose acetylsalicylic acid, also known as aspirin, can reduce inflammatory responses to sleep restriction.<\/p>\n

Results show that compared with placebo, preemptive administration of low-dose aspirin during sleep restriction reduced pro-inflammatory responses. Specifically, aspirin reduced interleukin-6 expression and COX-1\/COX-2 double positive cells in lipopolysaccharide-stimulated monocytes, as well as C-reactive protein serum levels.<\/p>\n

\u201cThe novelty of this study is that it investigated whether we can pharmacologically reduce the inflammatory consequences of sleep restriction,\u201d said lead author Larissa Engert, who has a doctorate in behavioral physiology and is a postdoctoral fellow in the department of neurology at Beth Israel Deaconess Medical Center and the division of sleep medicine at Harvard Medical School in Boston. \u201cWe used a non-steroidal, anti-inflammatory drug because it has been shown to affect specific inflammatory pathways, which were previously shown to be dysregulated by experimental sleep restriction or sleep disturbances.\u201d<\/p>\n

The researchers collected data from 46 healthy adults in a randomized placebo-controlled crossover trial with three protocols \u2013 sleep restriction\/aspirin, sleep restriction\/placebo, and control sleep\/placebo \u2013 each consisting of a 14-day at-home phase followed by an 11-day in-hospital stay. In the sleep restriction\/aspirin condition, participants took low-dose aspirin during the at-home phase and in-hospital stay. Each in-hospital stay started with two nights of an eight-hour sleep opportunity. Then, under the sleep restriction conditions, participants were exposed to five nights of a four-hour sleep opportunity, followed by three nights of recovery sleep. The control sleep condition provided an eight-hour sleep opportunity throughout the in-hospital stay. Sleep and immunologic measures were assessed at baseline and various points throughout the study.<\/p>\n

The data also reveal that the aspirin-induced reduction of inflammatory pathway activity in sleep-restricted participants was paralleled by decreased wake after sleep onset and increased sleep efficiency during recovery sleep, Engert noted.<\/p>\n

\u201cThese findings show that it is possible to blunt inflammatory pathways activated by sleep restriction through preemptive administration of low-dose aspirin. This may foster the development of new therapeutics that specifically target those pathways, and do not exhibit the undesirable side effects associated with aspirin, such as bleeding and stroke. Such therapeutics could complement behavioral sleep improvement therapies to better prevent or control inflammation and its consequences in those experiencing periods of sleep deficiency,\u201d Engert said.<\/p>\n

This study was supported by grants from the National Institutes of Health, German Research Foundation, and Sleep Research Society Foundation. The research abstract<\/a> was published recently in an online supplement<\/a> of the journal Sleep and will be presented Monday, June 3, and Wednesday, June 5, during SLEEP 2024 in Houston. SLEEP is the annual meeting of the Associated Professional Sleep Societies, a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society.<\/p>\n

###<\/p>\n

Abstract Title<\/strong>: Using Low-Dose Acetylsalicylic Acid to Target Inflammation in Response to Experimental Sleep Restriction in Humans<\/a>
\nAbstract ID<\/strong>: 0174
\nOral Presentation Date<\/strong>: Monday, June 3, from 1:45 – 2 p.m. CDT, Room 342DEF
\nPoster Presentation Date<\/strong>: Wednesday, June 5, from 11-11:45 a.m. CDT, Board 50
\nPresenter<\/strong>: Larissa Engert, Ph.D.<\/p>\n

For a copy of the abstract or to arrange an interview with the study author or a sleep expert, please send an email to media@aasm.org<\/a>.<\/p>\n

About the Associated Professional Sleep Societies, LLC<\/strong><\/p>\n

The APSS is a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society. The APSS organizes the SLEEP annual meeting each June.<\/p>\n

About the American Academy of Sleep Medicine
\n<\/strong>Established in 1975, the AASM advances sleep care and enhances sleep health to improve lives. The AASM has a combined membership of 12,000 accredited sleep centers and individuals, including physicians, scientists and other health care professionals who care for patients with sleep disorders. As the leader in the sleep field, the AASM sets standards and promotes excellence in sleep medicine health care, education and research (aasm.org<\/a>).<\/p>\n

About the Sleep Research Society\u00a0<\/strong><\/p>\n

The SRS is a professional membership society that advances sleep and circadian science. The SRS provides forums for the exchange of information, establishes and maintains standards of reporting and classifies data in the field of sleep research, and collaborates with other organizations to foster scientific investigation on sleep and its disorders. The SRS also publishes the peer-reviewed, scientific journals Sleep and Sleep Advances (sleepresearchsociety.org<\/a>).<\/p>\n","protected":false},"excerpt":{"rendered":"

DARIEN, IL \u2013 A new study to be presented at the SLEEP 2024 annual meeting found that low-dose acetylsalicylic acid, also known as aspirin, can […]<\/p>\n","protected":false},"author":7,"featured_media":10909,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[110],"tags":[],"class_list":["post-10908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release"],"yoast_head":"\nLow-dose aspirin reduces inflammation caused by sleep loss – SLEEP Meeting<\/title>\n<meta name=\"description\" content=\"A new study to be presented at SLEEP 2024 found that low-dose acetylsalicylic acid, also known as aspirin, can reduce inflammatory responses to sleep restriction.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Low-dose aspirin reduces inflammation caused by sleep loss – SLEEP Meeting\" \/>\n<meta property=\"og:description\" content=\"A new study to be presented at SLEEP 2024 found that low-dose acetylsalicylic acid, also known as aspirin, can reduce inflammatory responses to sleep restriction.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/\" \/>\n<meta property=\"og:site_name\" content=\"SLEEP Meeting\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-03T15:40:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.sleepmeeting.org\/wp-content\/uploads\/2024\/06\/SLEEP24_Abstract_174_595x325.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"595\" \/>\n\t<meta property=\"og:image:height\" content=\"325\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Lynn Celmer\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lynn Celmer\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/\",\"url\":\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/\",\"name\":\"Low-dose aspirin reduces inflammation caused by sleep loss – SLEEP Meeting\",\"isPartOf\":{\"@id\":\"https:\/\/www.sleepmeeting.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.sleepmeeting.org\/wp-content\/uploads\/2024\/06\/SLEEP24_Abstract_174_595x325.jpg\",\"datePublished\":\"2024-06-03T15:40:39+00:00\",\"author\":{\"@id\":\"https:\/\/www.sleepmeeting.org\/#\/schema\/person\/e5e8e669b82b4e8e9dfcff26259d026e\"},\"description\":\"A new study to be presented at SLEEP 2024 found that low-dose acetylsalicylic acid, also known as aspirin, can reduce inflammatory responses to sleep restriction.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#primaryimage\",\"url\":\"https:\/\/www.sleepmeeting.org\/wp-content\/uploads\/2024\/06\/SLEEP24_Abstract_174_595x325.jpg\",\"contentUrl\":\"https:\/\/www.sleepmeeting.org\/wp-content\/uploads\/2024\/06\/SLEEP24_Abstract_174_595x325.jpg\",\"width\":595,\"height\":325},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.sleepmeeting.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Low-dose aspirin reduces inflammation caused by sleep loss\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.sleepmeeting.org\/#website\",\"url\":\"https:\/\/www.sleepmeeting.org\/\",\"name\":\"SLEEP Meeting\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.sleepmeeting.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.sleepmeeting.org\/#\/schema\/person\/e5e8e669b82b4e8e9dfcff26259d026e\",\"name\":\"Lynn Celmer\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.sleepmeeting.org\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/5663d50b48a56e4b465c12dd52101697588188893462bb92e4d47c201a2ab319?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/5663d50b48a56e4b465c12dd52101697588188893462bb92e4d47c201a2ab319?s=96&d=mm&r=g\",\"caption\":\"Lynn Celmer\"},\"url\":\"https:\/\/www.sleepmeeting.org\/author\/lcelmer\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Low-dose aspirin reduces inflammation caused by sleep loss – SLEEP Meeting","description":"A new study to be presented at SLEEP 2024 found that low-dose acetylsalicylic acid, also known as aspirin, can reduce inflammatory responses to sleep restriction.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/","og_locale":"en_US","og_type":"article","og_title":"Low-dose aspirin reduces inflammation caused by sleep loss – SLEEP Meeting","og_description":"A new study to be presented at SLEEP 2024 found that low-dose acetylsalicylic acid, also known as aspirin, can reduce inflammatory responses to sleep restriction.","og_url":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/","og_site_name":"SLEEP Meeting","article_published_time":"2024-06-03T15:40:39+00:00","og_image":[{"width":595,"height":325,"url":"https:\/\/www.sleepmeeting.org\/wp-content\/uploads\/2024\/06\/SLEEP24_Abstract_174_595x325.jpg","type":"image\/jpeg"}],"author":"Lynn Celmer","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Lynn Celmer","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/","url":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/","name":"Low-dose aspirin reduces inflammation caused by sleep loss – SLEEP Meeting","isPartOf":{"@id":"https:\/\/www.sleepmeeting.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#primaryimage"},"image":{"@id":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#primaryimage"},"thumbnailUrl":"https:\/\/www.sleepmeeting.org\/wp-content\/uploads\/2024\/06\/SLEEP24_Abstract_174_595x325.jpg","datePublished":"2024-06-03T15:40:39+00:00","author":{"@id":"https:\/\/www.sleepmeeting.org\/#\/schema\/person\/e5e8e669b82b4e8e9dfcff26259d026e"},"description":"A new study to be presented at SLEEP 2024 found that low-dose acetylsalicylic acid, also known as aspirin, can reduce inflammatory responses to sleep restriction.","breadcrumb":{"@id":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#primaryimage","url":"https:\/\/www.sleepmeeting.org\/wp-content\/uploads\/2024\/06\/SLEEP24_Abstract_174_595x325.jpg","contentUrl":"https:\/\/www.sleepmeeting.org\/wp-content\/uploads\/2024\/06\/SLEEP24_Abstract_174_595x325.jpg","width":595,"height":325},{"@type":"BreadcrumbList","@id":"https:\/\/www.sleepmeeting.org\/low-dose-aspirin-reduces-inflammation-caused-by-sleep-loss\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sleepmeeting.org\/"},{"@type":"ListItem","position":2,"name":"Low-dose aspirin reduces inflammation caused by sleep loss"}]},{"@type":"WebSite","@id":"https:\/\/www.sleepmeeting.org\/#website","url":"https:\/\/www.sleepmeeting.org\/","name":"SLEEP Meeting","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sleepmeeting.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.sleepmeeting.org\/#\/schema\/person\/e5e8e669b82b4e8e9dfcff26259d026e","name":"Lynn Celmer","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.sleepmeeting.org\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/5663d50b48a56e4b465c12dd52101697588188893462bb92e4d47c201a2ab319?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/5663d50b48a56e4b465c12dd52101697588188893462bb92e4d47c201a2ab319?s=96&d=mm&r=g","caption":"Lynn Celmer"},"url":"https:\/\/www.sleepmeeting.org\/author\/lcelmer\/"}]}},"_links":{"self":[{"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/posts\/10908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/comments?post=10908"}],"version-history":[{"count":1,"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/posts\/10908\/revisions"}],"predecessor-version":[{"id":10910,"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/posts\/10908\/revisions\/10910"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/media\/10909"}],"wp:attachment":[{"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/media?parent=10908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/categories?post=10908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sleepmeeting.org\/wp-json\/wp\/v2\/tags?post=10908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}